Late onset of type 2 diabetes is associated with mitochondrial tRNATrp A5514G and tRNASer(AGY) C12237T mutations.

Liuchun YangQinxian GuoJianhang LengKeyi WangZhaochang Jiang

Published in: Journal of clinical laboratory analysis (2021)

Our findings suggest that m.A5514G and m.C12337T mutations are associated with T2DM, screening for mt-tRNA mutations is useful for molecular diagnosis and prevention of mitochondrial diabetes.

Keyphrases

late onset
type diabetes
glycemic control
oxidative stress
early onset
cardiovascular disease
adipose tissue
metabolic syndrome
skeletal muscle
single molecule