The EGFR-P38 MAPK axis up-regulates PD-L1 through miR-675-5p and down-regulates HLA-ABC via hexokinase-2 in hepatocellular carcinoma cells.

Zongcai LiuFen NingYanna CaiHuiying ShengRuidan ZhengXi YinZhikun LuLing SuXiaodan ChenChunhua ZengHaifang WangLi Liu

Published in: Cancer communications (London, England) (2021)

The EGFR-P38 MAPK axis could up-regulate PD-L1 through miR-675-5p and down-regulate HLA-ABC via HK2 in HCC cells. Our study reveals a novel signaling network that may cause immune suppression in HCC and suggests that EGFR signaling can be targeted for HCC immunotherapy.

Keyphrases

small cell lung cancer
epidermal growth factor receptor
tyrosine kinase
induced apoptosis
cell cycle arrest
cancer therapy
endoplasmic reticulum stress
oxidative stress
endothelial cells