Prognostic Significance and Biologic Associations of Senescence-Associated Secretory Phenotype Biomarkers in Heart Failure.
Oday SalmanPayman ZamaniLei ZhaoMarie-Joe DibSushrima GanJoe David AzzoBianca PourmussaArthur Mark RichardsAli JavaheriDouglas L MannErnst R RietzschelManyun ZhaoZhaoqing WangChristina EbertLaura LiuKushan L GunawardhanaDanielle GreenawaltLeon CarayannopoulosChing-Pin ChangVanessa P M van EmpelJoseph GogainPeter H SchaferDavid A GordonFrancisco Ramirez-ValleThomas P CappolaJulio Alonso ChirinosPublished in: Journal of the American Heart Association (2024)
Increased SASP components are independently associated with adverse outcomes in HF. Biologic pathways associated with SASP are predominantly related to coagulation, inflammation, and cell metabolism.