The Role of ERK1/2 Pathway in the Pathophysiology of Alzheimer's Disease: An Overview and Update on New Developments.
Mohammad Rafi KhezriKeyvan YousefiAyda EsmaeiliMorteza Ghasemnejad BerenjiPublished in: Cellular and molecular neurobiology (2022)
Alzheimer's disease (AD) is the most common neurodegenerative disorder worldwide. Several findings suggest that correcting the dysregulated signaling pathways may offer a potential therapeutic approach in this disease. Extracellular signal-regulated kinase 1/2 (ERK1/2), a member of the mitogen-activated protein kinase family, plays a major role in regulation of cell proliferation, autophagy process, and protein synthesis. The available literature suggests dysregulated ERK1/2 in AD patients with potential implications in the multifaceted underlying pathologies of AD, including amyloid-β plaque formation, tau phosphorylation, and neuroinflammation. In this regard, in the current review, we aim to summarize the reports on the potential roles of ERK1/2 in AD pathophysiology.
Keyphrases
- signaling pathway
- cell proliferation
- pi k akt
- protein kinase
- cognitive decline
- epithelial mesenchymal transition
- induced apoptosis
- systematic review
- cell death
- cell cycle
- coronary artery disease
- traumatic brain injury
- endoplasmic reticulum stress
- lps induced
- inflammatory response
- risk assessment
- climate change
- blood brain barrier
- mild cognitive impairment