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Antihyperuricemic and xanthine oxidase inhibitory activities of Tribulus arabicus and its isolated compound, ursolic acid: In vitro and in vivo investigation and docking simulations.

Eman Abu-GharbiehNaglaa G ShehabIhab M AlmasriYasser Bustanji
Published in: PloS one (2018)
The activity of the ethanolic extract of T. arabicus and its n-hexane fraction can be attributed to the isolated compound, ursolic acid. Ursolic acid has good hypouricemic activity and therefore has high potential to be used for the treatment of gout and hyperuricemia-related diseases.
Keyphrases
  • uric acid
  • molecular dynamics
  • metabolic syndrome
  • small molecule