Treatment Response Evaluation of Cardiac Amyloidosis Using Serial T1- and T2-Mapping Cardiovascular Magnetic Resonance Imaging.
Jinwoo SonYoo Jin HongPublished in: Taehan Yongsang Uihakhoe chi (2020)
Amyloidosis is a multisystemic disease characterized by the accumulation of abnormal proteins in extracellular spaces in various organs, with frequent involvement of the myocardium. We report a case of a patient who had cardiac amyloidosis with a trend of reduction in native T1 and T2 values and extracellular volume fraction on serial cardiac magnetic resonance imaging after chemotherapy and stem cell transplantation. The native T1 value and the extracellular volume fraction are closely associated with tissue amyloid burden in amyloidosis patients. This case demonstrated that cardiac magnetic resonance imaging may be used as a non-invasive and quantitative biomarker in the treatment monitoring of amyloidosis.
Keyphrases
- magnetic resonance imaging
- stem cell transplantation
- left ventricular
- multiple myeloma
- computed tomography
- high dose
- end stage renal disease
- contrast enhanced
- ejection fraction
- heart failure
- squamous cell carcinoma
- case report
- prognostic factors
- locally advanced
- radiation therapy
- peritoneal dialysis
- mass spectrometry
- rectal cancer
- diffusion weighted imaging
- patient reported outcomes
- combination therapy