Five-Year Follow-Up of Coronary Microvascular Dysfunction and Coronary Artery Disease in Systemic Lupus Erythematosus: Results From a Community-Based Lupus Cohort.
Vaneet K SandhuJanet WeiLouise E J ThomsonDaniel S BermanJay SchapiraDaniel WallaceMichael H WeismanC Noel Bairey MerzMariko L IshimoriPublished in: Arthritis care & research (2020)
At the 5-year follow-up of SLE subjects with CP who were evaluated at baseline and follow-up, a majority had persistent CP, and nearly one-half had similar or worse myocardial perfusion consistent with CMD without obstructive CAD. These findings propose an alternative explanation for CP in SLE subjects compared to the more common SLE-related accelerated obstructive CAD accounting for CP and adverse outcomes. These findings support further studies of CMD as an etiology for cardiac morbidity and mortality in SLE.
Keyphrases
- systemic lupus erythematosus
- coronary artery disease
- disease activity
- percutaneous coronary intervention
- cardiovascular events
- coronary artery bypass grafting
- rheumatoid arthritis
- oxidative stress
- left ventricular
- coronary artery
- aortic stenosis
- type diabetes
- cardiovascular disease
- heart failure
- acute coronary syndrome