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Extracorporeal cardiopulmonary resuscitation: a national study on the association between favourable neurological status and biomarkers of hypoperfusion, inflammation, and organ injury.

Emilie GregersSivagowry Rasalingam MørkLouise LindeJo Bønding AndreasenMorten Holdgaard SmerupJesper KjærgaardPeter Hasse Møller-SørensenLene HolmvangSteffen ChristensenChristian Juhl TerkelsenMariann TangJacob Eifer MøllerJens Flensted LassenHenrik SchmidtLars Peter RiberMatilde Winther-JensenSisse ThomassenHelle LaugesenChristian HassagerHelle Søholm
Published in: European heart journal. Acute cardiovascular care (2022)
Biomarkers of hypoperfusion (lactate), inflammation (leucocytes), and organ injury (ALP and CK-MB) were independently associated with neurological status at hospital discharge. Biomarkers of hypoperfusion and inflammation (at hospital admission) and organ injury (days 1 and 2 after ECPR) may aid in the clinical decision of when to prolong or terminate ECPR in cases of refractory OHCA.
Keyphrases
  • cardiopulmonary resuscitation
  • cardiac arrest
  • oxidative stress
  • cognitive impairment
  • emergency department
  • healthcare
  • protein kinase
  • acute care