CIP2A regulates MYC translation (via its 5'UTR) in colorectal cancer.

S DenkS SchmidtY SchurrG SchwarzF SchoteM DiefenbacherC ArmendarizF DejureM EilersArmin Wiegering

Published in: International journal of colorectal disease (2020)

Thus, instead of targeting MYC protein stability as reported for other tissue types before, CIP2A specifically regulates MYC mRNA translation in CRC but has only slight effects on global mRNA translation. In conclusion, we propose as novel mechanism that CIP2A regulates MYC on a translational level rather than affecting MYC protein stability in CRC.

Keyphrases

transcription factor
binding protein
protein protein
amino acid
small molecule