pH-activated, mitochondria-targeted, and redox-responsive delivery of paclitaxel nanomicelles to overcome drug resistance and suppress metastasis in lung cancer.

He WangWenwen ShiDanning ZengQiudi HuangJiacui XieHuaying WenJinfang LiXiyong YuLinghao QinYi Zhou

Published in: Journal of nanobiotechnology (2021)

These promising results indicated that acid-activated mitochondria-targeting and redox-responsive nanomicelles potentially represent a significant advancement in cancer treatment. GRAPHIC ABSTARCT.

Keyphrases

cancer therapy
drug delivery
cell death
reactive oxygen species
endoplasmic reticulum
chemotherapy induced