Germacrane-Type Sesquiterpene Lactones from Achillea millefolium L. and Their Anti-Inflammatory Activity.
Hongliang LiHaji Akber AisaJun LiPublished in: Chemistry & biodiversity (2023)
Six undescribed germacrane-type sesquiterpene lactones, millefoliumons A-F, and two known analogs were isolated from the ethyl acetate fraction of the whole plant of Achillea millefolium L. growing in Xinjiang, China. The structures of these compounds were fully elucidated by their 1D and 2D nuclear magnetic resonance (NMR), and high resolution mass (HR-ESI-MS) spectral data, and comparison with literatures. The absolute configurations of millefoliumons A-F were confirmed by experimental and calculated electronic circular dichroism data (ECD), and 13 C-NMR calculations and DP4+ probability analysis. All compounds displayed the approximate tendency to inhibit the nitric oxide (NO) release in lipopolysaccharide (LPS)-induced BV2 cells.
Keyphrases
- lps induced
- high resolution
- magnetic resonance
- inflammatory response
- nitric oxide
- mass spectrometry
- ms ms
- electronic health record
- induced apoptosis
- big data
- lipopolysaccharide induced
- multiple sclerosis
- cell cycle arrest
- toll like receptor
- solid state
- optical coherence tomography
- contrast enhanced
- molecular dynamics simulations
- immune response
- density functional theory
- nitric oxide synthase
- data analysis
- molecular docking
- magnetic resonance imaging
- tandem mass spectrometry
- high speed
- liquid chromatography
- signaling pathway