Stem Cells in Autologous Microfragmented Adipose Tissue: Current Perspectives in Osteoarthritis Disease.
Francesco De FrancescoPasquale GravinaAlice BusatoLuca FarinelliCarlo SoranzoLuis VidalNicola ZingarettiBarbara ZavanAndrea SbarbatiMichele RiccioAntonio GigantePublished in: International journal of molecular sciences (2021)
Osteoarthritis (OA) is a chronic debilitating disorder causing pain and gradual degeneration of weight-bearing joints with detrimental effects on cartilage volume as well as cartilage damage, generating inflammation in the joint structure. The etiology of OA is multifactorial. Currently, therapies are mainly addressing the physical and occupational aspects of osteoarthritis using pharmacologic pain treatment and/or surgery to manage the symptomatology of the disease with no specific regard to disease progression or prevention. Herein, we highlight alternative therapeutics for OA specifically considering innovative and encouraging translational methods with the use of adipose mesenchymal stem cells.
Keyphrases
- knee osteoarthritis
- adipose tissue
- stem cells
- chronic pain
- mesenchymal stem cells
- rheumatoid arthritis
- oxidative stress
- pain management
- physical activity
- neuropathic pain
- cell therapy
- insulin resistance
- minimally invasive
- bone marrow
- body mass index
- extracellular matrix
- coronary artery bypass
- umbilical cord
- mental health
- high fat diet
- small molecule
- spinal cord injury
- type diabetes
- skeletal muscle
- combination therapy
- replacement therapy
- drug induced
- surgical site infection
- atrial fibrillation
- percutaneous coronary intervention