A dynamic single cell-based framework for digital twins to prioritize disease genes and drug targets.

Xinxiu LiEun Jung LeeSandra LiljaJoseph LoscalzoSamuel SchäferMartin SmelikMaria Regina StroblOleg SysoevHui WangHuan ZhangYelin ZhaoDanuta R GawelBarbara BohleMikael Benson

Published in: Genome medicine (2022)

We present a scalable framework for modeling dynamic changes in digital twins, on cellulome- and genome-wide scales, to prioritize UR genes for biomarker and drug discovery.

Keyphrases

genome wide
drug discovery
dna methylation
single cell
copy number
bioinformatics analysis
gestational age
rna seq
genome wide identification
high throughput
gene expression
adverse drug