Comparative Risk of Opioid Overdose With Concomitant Use of Prescription Opioids and Skeletal Muscle Relaxants.

Nazleen F KhanKatsiaryna BykovMichael L BarnettRobert J GlynnSeanna M VineJoshua J Gagne

Published in: Neurology (2022)

Concomitant use of prescription opioids and baclofen relative to cyclobenzaprine is associated with opioid overdose. Clinical interventions may focus on prescribing alternatives in the same drug class or providing access to opioid antagonists if treatment with both medications is necessary for pain management.

Keyphrases

pain management
chronic pain
skeletal muscle
primary care
insulin resistance
adverse drug
emergency department
drug induced
replacement therapy