Antithrombotic potential of a single-domain antibody enhancing the activated protein C-cofactor activity of protein S.
Josepha C SedzroFrédéric AdamClaire AuditeauElsa P BianchiniAllan De CarvalhoIvan PeyronSadyo DaraméSophie GandrilleStella L G D ThomassenTilman M HackengOlivier D ChristophePeter J LentingCecile V DenisDelphine BorgelFrançois SallerPublished in: Journal of thrombosis and haemostasis : JTH (2022)
Altogether, these results showed that pharmacological enhancement of the APC-cofactor activity of PS through an original anti-PS sdAb might constitute a promising and safe antithrombotic strategy.