The association between areas of secondary hyperalgesia and volumes of the caudate nuclei and other pain relevant brain structures-A 3-tesla MRI study of healthy men.
Morten Sejer HansenMohammad S AsgharJørn WetterslevChristian B PipperJohan MårtenssonLino BecerraAnders ChristensenJanus D NybingInger HavsteenMikael BoesenJørgen B DahlPublished in: PloS one (2018)
Our findings indicate that the size of the secondary hyperalgesia area is not associated with the volume of brain structures relevant for pain processing, suggesting that the propensity to develop central sensitization, assessed as secondary hyperalgesia, is not correlated to brain structure volume.