FTZ Ameliorates Diabetic Cardiomyopathy by Inhibiting Inflammation and Cardiac Fibrosis in the Streptozotocin-Induced Model.

Lexun WangHuijuan WuYanyue DengShengxi ZhangQuxing WeiQianqian YangShenghua PiaoWeijian BeiXianglu RongJiao Guo

Published in: Evidence-based complementary and alternative medicine : eCAM (2021)

Our results suggest that FTZ exhibits therapeutic properties against DCM by ameliorating hyperglycemia-induced inflammation and fibrosis via at least partial inhibition of AKT, ERK, and STAT3 signaling pathways.

Keyphrases

diabetic rats
signaling pathway
oxidative stress
cell proliferation
high glucose
pi k akt
type diabetes
epithelial mesenchymal transition
drug induced
high fat diet
left ventricular
skeletal muscle
liver fibrosis
atrial fibrillation
insulin resistance
endoplasmic reticulum stress