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Insights into platelet pharmacology from a cryo-EM structure of the ABCC4 transporter.

Anish V ShardaSean X GuJohn Hwa
Published in: Nature cardiovascular research (2023)
Structural determination of the ABCC4 transporter is a major first step in providing crucial molecular insights into the transport of platelet substrates into granules, as well as drug transport from platelets. The findings provide a framework for understanding platelet interactions and potential design of specific platelet antagonists.
Keyphrases
  • emergency department
  • solid phase extraction
  • mass spectrometry
  • high resolution
  • adverse drug
  • simultaneous determination