Assessment of MGMT methylation status using high-performance liquid chromatography in newly diagnosed glioblastoma.

Mitsuto HaniharaKunio MiyakeAtsushi WatanabeYuriko YamadaNaoki OishiTomoyuki KawatakiTakeshi InukaiTetsuo KondoHiroyuki Kinouchi

Published in: Clinical epigenetics (2020)

The combination of our HPLC method and the original primer setting provides a new standard method for determination of MGMT methylation status in patients with GBM and is useful for refining MGMT-based drug selection.

Keyphrases

high performance liquid chromatography
solid phase extraction
simultaneous determination
tandem mass spectrometry
newly diagnosed
mass spectrometry
molecularly imprinted
genome wide
dna methylation
ms ms
liquid chromatography
drug induced
electronic health record