Genetic contributions to female gout and hyperuricemia using genome-wide association study and polygenic risk score analyses.
Chien-Yu LinYa-Sian ChangTing-Yuan LiuChung-Ming HuangChin-Chun ChungYu-Chia ChenFuu-Jen TsaiJan-Gowth ChangShun-Jen ChangPublished in: Rheumatology (Oxford, England) (2022)
The variants in gene SLC2A9 are the major genetic factors for females associated with gout in those aged > = 50. PRS can provide more robust prediction of the gout/AH under homogeneous selection of variants which show effects on the traits.