Histopathological and genetic features of mismatch repair-deficient high-grade prostate cancer.

Nicolas WyvekensHarrison K TsaiLynette M ShollJonathan TucciGiovanna A Giannico Jennifer B GordetskyMichelle S HirschJustine A BarlettaAndres Martin Acosta

Published in: Histopathology (2022)

MMR deficiency was most commonly secondary to inactivation of MSH2/MSH6 in this study. Importantly, MMR-deficient high-grade prostatic adenocarcinomas had morphological features that might be useful to identify selected cases for MMR immunohistochemistry.

Keyphrases

high grade
prostate cancer
low grade
radical prostatectomy
genome wide
copy number
benign prostatic hyperplasia
dna methylation