Type I interferon induces cancer stem cells-mediated chemotherapy resistance.

Published in: Oncoimmunology (2022)

In a recent study in Nature Immunology , Musella et al . demonstrate that suboptimal type I interferon (IFN-I) signaling in tumors undergoing immunogenic cell death (ICD) facilitates the accumulation of cancer stem cells (CSCs) by triggering the epigenetic regulator lysine demethylase 1B (KDM1B). KDM1B stands out as a promising target for the development of novel strategies to improve anti-cancer responses driven by ICD.

Keyphrases

cancer stem cells
cell death
dendritic cells
dna methylation
gene expression
immune response
locally advanced
signaling pathway
amino acid