Anti-Gephyrin antibodies: A novel specificity in patients with systemic sclerosis and lower bowel dysfunction.

Zsuzsanna H McMahanSubhash KulkarniFelipe AndradeJamie PerinChengxiu ZhangJody E HooperFredrick M WigleyAntony RosenPankaj J PasrichaLivia A Casciola-Rosen

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2023)

Gephyrin is a novel ENS autoantigen that is expressed in human myenteric ganglia. Anti-gephyrin autoantibodies are associated with the presence and severity of constipation in SSc patients.

Keyphrases

systemic sclerosis
interstitial lung disease
end stage renal disease
endothelial cells
ejection fraction
newly diagnosed
systemic lupus erythematosus
prognostic factors
peritoneal dialysis
oxidative stress
patient reported outcomes