Dinutuximab Synergistically Enhances the Cytotoxicity of Natural Killer Cells to Retinoblastoma Through the Perforin-Granzyme B Pathway.

Huixue WangJie YangHui PanMei Chee Tai Mohamed H MaherRenbing JiaShengfang GeLinna Lu

Published in: OncoTargets and therapy (2020)

This study indicates that retinoblastoma impairs the integrity of the BRB and contributes to dysregulated immune cell infiltrates. GD2 is a specific target for natural killer (NK) cell-based immunotherapy and that the combination of dinutuximab and NK-92MIhCD16-GFP cells exerts potent antitumor effects through antibody-dependent cell-mediated cytotoxicity.

Keyphrases

nk cells
natural killer cells
induced apoptosis
single cell
cell cycle arrest
cell therapy
oxidative stress