Comprehensive characterization of cell-free tumor DNA in plasma and urine of patients with renal tumors.
Christopher G SmithTina MoserFlorent MouliereJohanna Field-RaynerMatthew EldridgeAnja L RiedigerDineika ChandranandaKatrin HeiderJonathan C M WanAnne Y WarrenJames MorrisIrena HudecovaWendy N CooperThomas J MitchellDavina GaleAndrea Ruiz-ValdepenasTobias KlatteStephan UrsprungEvis SalaAntony C P RiddickTevita F AhoJames N ArmitageSamantha PerakisMartin PichlerMaximilian SelesGabriel WcisloSarah J WelshAthena MatakidouTim EisenCharles E MassieNitzan RosenfeldEllen HeitzerGrant D StewartPublished in: Genome medicine (2020)
These data highlight RCC as a ctDNA-low malignancy. The biological reasons for this are yet to be determined. Nonetheless, our findings indicate potential clinical utility in the management of patients with renal tumors, provided improvement in isolation and detection approaches.