A systematic review of the antidepressant effects of curcumin: Beyond monoamines theory.

Julia Novaes MatiasGabriela AcheteGyovanna Sorrentino Dos Santos CampanariÉlen Landgraf GuiguerAdriano Cressoni AraújoDaiene Santos BuglioSandra Maria Barbalho

Published in: The Australian and New Zealand journal of psychiatry (2021)

Curcumin improves depressant and anxiety behavior in humans. It can increase monoamines and brain-derived neurotrophic factor levels and may inhibit the production of pro-inflammatory cytokines and neuronal apoptosis in the brain. Systemically, curcumin enhanced insulin sensitivity, reduced cortisol levels, and reversed metabolic abnormalities. Studies with larger samples and standardized dose and formulation are required to demonstrate the benefits of curcumin in depression treatment since there are many variations in this compound's use.

Keyphrases

oxidative stress
sleep quality
depressive symptoms
drug delivery
endoplasmic reticulum stress
white matter
cerebral ischemia
resting state
cell cycle arrest
signaling pathway