Polygenic Risk Score Predicts Earlier-Onset Adult Systemic Lupus Erythematosus and First-Year Renal Diseases in a Taiwanese Cohort.
Yen-Ju ChenTzu-Hung HsiaoYing-Cheng LinWen-Juei JengChien-Lin MaoChia-Yi WeiYi-Chung HsiehChih-Jen HuangMei-Hung PanI-Chieh ChenChing-Heng LinYi Ming ChenHwai-I YangPublished in: RMD open (2024)
PRS of SLE is associated with earlier onset, renal involvement within the first year of SLE diagnosis and seropositivity in Taiwanese patients. Integrating PRS with clinical decision-making may enhance lupus nephritis screening and early treatment to improve renal outcomes in patients with SLE.
Keyphrases
- systemic lupus erythematosus
- disease activity
- end stage renal disease
- decision making
- newly diagnosed
- chronic kidney disease
- ejection fraction
- rheumatoid arthritis
- peritoneal dialysis
- prognostic factors
- metabolic syndrome
- adipose tissue
- skeletal muscle
- insulin resistance
- weight loss
- combination therapy
- replacement therapy
- smoking cessation