Novel evidence that the P2X1 purinergic receptor-Nlrp3 inflammasome axis orchestrates optimal trafficking of hematopoietic stem progenitors cells.

Kamila BujkoMateusz AdamiakAhmed Abdelbaset-IsmailArjun ThapaNicoletta IlowskaJanina RatajczakMagdalena KuciaMariusz Z Ratajczak

Published in: Folia histochemica et cytobiologica (2022)

This study demonstrates for the first time the novel role of the P2X1 receptor in HSPCs trafficking in the mouse. Furthermore, it supports an important role of purinergic signaling engaging its downstream target Nlrp3 inflammasome in the mobilization, homing and engraftment of HSPCs.

Keyphrases

binding protein
nlrp inflammasome
induced apoptosis
cell cycle arrest
oxidative stress
signaling pathway
cell proliferation