RhoA/ROCK signalling activated by ARHGEF3 promotes muscle weakness via autophagy in dystrophic mdx mice.

Jae-Sung YouYongdeok KimSoohyun LeeRashid BashirJie Chen

Published in: Journal of cachexia, sarcopenia and muscle (2023)

Our findings uncover a new pathological mechanism of muscle weakness in DMD involving the ARHGEF3-ROCK-autophagy pathway and the therapeutic potential of targeting ARHGEF3 in DMD.

Keyphrases

duchenne muscular dystrophy
cell death
endoplasmic reticulum stress
skeletal muscle
signaling pathway
oxidative stress
muscular dystrophy
high fat diet induced
type diabetes
cancer therapy
insulin resistance
wild type