Altered innate immune profile in blood of systemic mastocytosis patients.
Alba Pérez-PonsMaría Jara-AcevedoAna HenriquesPaula Navarro-NavarroAndrés C García-MonteroIván Álvarez-TwoseCarlos E PedreiraLaura Sánchez-MuñozDaniela DamascenoCarolina CaldasJavier I Muñoz-GonzálezAlmudena MatitoJuan A Flores-MonteroOscar González-LópezIgnacio CriadoAndrea MayadoAlberto OrfaoPublished in: Clinical and translational allergy (2022)
These results demonstrate an altered distribution of blood monocytes and DC subsets in SM associated with constitutive activation of functionally impaired blood monocytes and increased plasma levels of a wide variety of inflammatory cytokines, reflecting broad activation of the innate immune response in mastocytosis.