Population pharmacokinetics of clonazepam in saliva and plasma: Steps towards noninvasive pharmacokinetic studies in vulnerable populations.
Matthijs D KruizingaRob G J A ZuikerKirsten R BergmannAnnelies C EgasAdam F CohenGijs W E SantenMichiel Joost van EsdonkPublished in: British journal of clinical pharmacology (2021)
The developed model described the salivary and plasma kinetics of clonazepam, and could predict steady-state trough plasma concentrations based on saliva concentrations with acceptable accuracy.
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