Activation of mitochondrial unfolded protein response is associated with Her2-overexpression breast cancer.

Fang-Ming ChenLi-Ju HuangFu Ou-YangJung-Yu KanLi-Chun KaoMing-Feng Hou

Published in: Breast cancer research and treatment (2020)

We observed that mtUPR was specifically activated in breast cancer tissues but inactivated in normal mammary tissue. MtUPR had also exhibited a particular increase in Her2-overexpression tumors but not in ER- or PR-positive tumors. Taken together, we suggested that mtUPR may act as a potential candidate for developing novel Her2-overexpression breast cancer therapy.

Keyphrases

cell proliferation
cancer therapy
transcription factor
gene expression
drug delivery
endoplasmic reticulum
endoplasmic reticulum stress
protein protein
risk assessment
amino acid
breast cancer cells
climate change
breast cancer risk