Extensive virologic and immunologic characterization in an HIV-infected individual following allogeneic stem cell transplant and analytic cessation of antiretroviral therapy: A case study.
Nathan W CumminsStacey RizzaMark R LitzowStephane HuaGuinevere Q LeeKevin EinkaufTae-Wook ChunFrank RhameJason V BakerMichael P BuschNicolas ChomontPatrick G DeanRemi FromentinAshley T HaaseDylan HamptonSheila M KeatingSteven M LadaTzong-Hae LeeSekar NatesampillaiDouglas D RichmanTimothy W SchackerStephen WietgrefeXu G YuJoseph D YaoJohn ZeuliMathias LichterfeldAndrew D BadleyPublished in: PLoS medicine (2017)
allo-SCT led to a significant reduction in the size of the HIV-1 reservoir and a >9-month-long ART-free remission from HIV-1 replication. Phylogenetic analyses suggest that the origin of rebound virus was distinct from the viruses identified pre-transplant in the PBMCs.