Impaired Bone Microarchitecture in Premenopausal Women With Acromegaly: The Possible Role of Wnt Signaling.

Paula P B SilvaRosa M R PereiraLiliam TakayamaClarissa G BorbaFelipe H DuarteEricka B TrarbachRegina Matsunaga MartinMarcello D BronsteinNicholas A TritosRaquel Soares Jallad

Published in: The Journal of clinical endocrinology and metabolism (2021)

Eugonadal women with acromegaly without any pituitary deficiency showed increased cortical BMD, impairment of trabecular bone microstructure, and increased VF. Sclerostin was not correlated with any HR-pQCT parameters; however, DKK1 was correlated with cortical porosity in tibia (P = 0.027). Additional studies are needed to clarify the role of Wnt inhibitors on bone microarchitecture impairment in acromegaly.

Keyphrases

bone mineral density
postmenopausal women
growth hormone
soft tissue
bone loss
stem cells
body composition
white matter
multiple sclerosis