Evaluation of glymphatic-meningeal lymphatic system with intravenous gadolinium-based contrast-enhancement in cerebral small-vessel disease.
Miaoyi ZhangJie TangDing XiaYang XueXue RenQi HuangLangfeng ShiWeijun TangJianhui FuPublished in: European radiology (2023)
• Signal intensity changes in regions representing the glymphatic-meningeal lymphatic system (GMLS) can reflect the drainage function based on contrast-enhanced 3D-FLAIR and 3D T1-weighted MRI. • Impaired drainage of the GMLS in patients with high-burden CSVD can be visually evaluated using dynamic intravenous contrast-enhanced MRI. • This direct, noninvasive technique could serve as a basis for further GMLS studies and could help to explore a new therapeutic target in CSVD patients.
Keyphrases
- contrast enhanced
- magnetic resonance imaging
- diffusion weighted
- magnetic resonance
- computed tomography
- diffusion weighted imaging
- end stage renal disease
- lymph node
- ejection fraction
- high dose
- newly diagnosed
- chronic kidney disease
- ultrasound guided
- prognostic factors
- peritoneal dialysis
- subarachnoid hemorrhage
- dual energy
- low dose
- high intensity
- cerebral ischemia