Metabolomic profile of diet-induced obesity mice in response to humanin and small humanin-like peptide 2 treatment.

Hemal H MehtaJialin XiaoRicardo RamirezBrendan MillerSu-Jeong KimPinchas CohenKelvin Yen

Published in: Metabolomics : Official journal of the Metabolomic Society (2019)

The present study indicates that humanin and SHLP2 can lower several markers associated with age-related metabolic disorders. With the previous understanding of the effects of humanin and SHLP2 on cardiovascular function, insulin sensitization, and anti-inflammation, this metabolomic discovery provides a more comprehensive molecular explanation of the mechanism of action for humanin and SHLP2 treatment.

Keyphrases

type diabetes
oxidative stress
high fat diet induced
metabolic syndrome
weight loss
combination therapy
high throughput
skeletal muscle
glycemic control
smoking cessation
wild type