Genetic Variants Determine Treatment Response in Autoimmune Hepatitis.

Stephan ZandanellLorenz BalcarGeorg SemmlerAlex SchirmerIsabella LeitnerLea RosenstatterDavid NiederseerKarl SotlarAnna Maria SchneiderMichael StrasserSophie GenslucknerAlexandra FeldmanChristian DatzElmar Aigner

Published in: Journal of personalized medicine (2023)

Our data suggest that genetic risk variants impact the treatment response of AIH in a gene-dosage-dependent manner. Furthermore, MBOAT7 and PNPLA3 mediated most of the observed effects, the latter explaining, in part, the predisposition of male subjects to worse treatment responses.

Keyphrases

copy number
genome wide
multiple sclerosis
dna methylation
big data
replacement therapy