Enhanced anticancer activity and endocytic mechanisms by polymeric nanocarriers of n-butylidenephthalide in leukemia cells.

X-F HuangP-T ChenY-L LinM-S LeeK-F ChangK-W LiaoG-T SheuM-C HsiehNu-Man Tsai

Published in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2020)

LPPC encapsulation enhanced the cytotoxic activity of BP and did not influence the effects of BP induction that suggested LPPC-encapsulated BP might be developed as anti-leukemia drugs in future.

Keyphrases

drug delivery
acute myeloid leukemia
induced apoptosis
bone marrow
cancer therapy
drug release
cell cycle arrest
oxidative stress
pi k akt