Urate-Lowering Therapy Inhibits Thoracic Aortic Aneurysm and Dissection Formation in Mice.
Liu YangHao WuCongcong LuoYang ZhaoRongbo DaiZhiqing LiXu ZhangZe GongZeyu CaiYicong ShenFang YuWei LiHongmei ZhaoTao ZhangJunming ZhuYi FuJiangning LiuWei KongPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
This study uncovered an important and previously unrecognized role of hyperuricemia in mediating the pathogenesis of TAAD, and uric acid-lowering drug may represent a promising therapeutic approach for TAAD.