FHL2 promotes the aggressiveness of lung adenocarcinoma by inhibiting autophagy via activation of the PI3K/AKT/mTOR pathway.

Shuaishuai WangBaomo LiuYan SuNian WangPeixin DongXiongye XuLixia HuangShaoli LiJincui GuYanli QiuJiating DengZiying LinYanbin Zhou

Published in: Thoracic cancer (2024)

FHL2 promotes the progression of LUAD by activating the PI3K/AKT/mTOR pathway and subsequently inhibiting autophagy, which can be exploited as a potential therapeutic target for LUAD.

Keyphrases

signaling pathway
cell death
endoplasmic reticulum stress
oxidative stress
risk assessment
climate change