Virtual Screening of Small Molecular Inhibitors against DprE1.
Gang ZhangSong GuoHuaqing CuiJianguo QiPublished in: Molecules (Basel, Switzerland) (2018)
Decaprenylphosphoryl-β-d-ribose oxidase (DprE1) is the flavoprotein subunit of decaprenylphosphoryl-d-ribose epimerase involved in cell wall synthesis in Mycobacterium tuberculosis and catalyzes the conversion of decaprenylphosphoryl ribose to decaprenylphosphoryl arabinose. DprE1 is a potential target against tuberculosis, including multidrug-resistant tuberculosis. We identified potential DprE1 inhibitors from the ChemDiv dataset through virtual screening based on pharmacophore and molecular docking. Thirty selected compounds were subjected to absorption, distribution, metabolism, excretion, and toxicity prediction with the Discovery Studio software package. Two compounds were obtained as hits for inhibiting DprE1 activity in M. tuberculosis and are suitable for further in vitro and in vivo evaluation.
Keyphrases
- mycobacterium tuberculosis
- molecular docking
- cell wall
- pulmonary tuberculosis
- multidrug resistant
- molecular dynamics simulations
- small molecule
- signaling pathway
- drug resistant
- oxidative stress
- high throughput
- molecular dynamics
- acinetobacter baumannii
- klebsiella pneumoniae
- human health
- gram negative
- single cell
- escherichia coli
- pseudomonas aeruginosa