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A pair of new chromone enantiomers from Xylaria nigripes .

Jing LiYue-Ping JiangLan-Qing LiHong-Ping LongHai-Tao LiuRong YangManhua LiuWen-Xuan WangJi-Kai Liu
Published in: Natural product research (2022)
A pair of new chromone derivative enantiomers, (+)-xylarichromone A ( 1a ) and (-)-xylarichromone A ( 1b ), were isolated from the solid fermentation of Xylaria nigripes . The planar structure of 1 was determined by extensive NMR spectroscopic data, and its absolute configuration was assigned by comparison the ECD spectra with the known chromone derivatives. Compound 1 was the first chromone derivative reported from this medicinal fungus. The neuroprotective effects of 1 against oxygen and glucose deprivation (OGD) induced pheochromocytoma-12 cells (PC12) injury was investigated.
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