A pair of new chromone enantiomers from Xylaria nigripes .
Jing LiYue-Ping JiangLan-Qing LiHong-Ping LongHai-Tao LiuRong YangManhua LiuWen-Xuan WangJi-Kai LiuPublished in: Natural product research (2022)
A pair of new chromone derivative enantiomers, (+)-xylarichromone A ( 1a ) and (-)-xylarichromone A ( 1b ), were isolated from the solid fermentation of Xylaria nigripes . The planar structure of 1 was determined by extensive NMR spectroscopic data, and its absolute configuration was assigned by comparison the ECD spectra with the known chromone derivatives. Compound 1 was the first chromone derivative reported from this medicinal fungus. The neuroprotective effects of 1 against oxygen and glucose deprivation (OGD) induced pheochromocytoma-12 cells (PC12) injury was investigated.
Keyphrases
- induced apoptosis
- magnetic resonance
- high glucose
- high resolution
- molecular docking
- cell cycle arrest
- electronic health record
- big data
- water soluble
- diabetic rats
- oxidative stress
- blood glucose
- type diabetes
- machine learning
- signaling pathway
- adipose tissue
- atomic force microscopy
- artificial intelligence
- saccharomyces cerevisiae
- molecular dynamics simulations
- stress induced
- single molecule