Early Intrathecal T Helper 17.1 Cell Activity in Huntington Disease.

Marina Rode von EssenMarie N N HellemTua Vinther-JensenCecilie AmmitzbøllRikke H HansenLena E HjermindTroels T NielsenJørgen E NielsenFinn Sellebjerg

Published in: Annals of neurology (2019)

These data suggest that Th17.1 cells are implicated in the earliest pathogenic phases of HD and suggest that treatment to dampen T -cell-driven inflammation before motor onset might be of benefit in HTT gene expansion carriers. ANN NEUROL 2020;87:246-255.

Keyphrases

induced apoptosis
oxidative stress
single cell
cell cycle arrest
cell therapy
regulatory t cells
genome wide
electronic health record
copy number
dna methylation
machine learning
mesenchymal stem cells
deep learning
replacement therapy