In situ setup for screening of drug permeation by NMR spectroscopy.

Malte MildnerSimon HanioSebastian EndresLena SchellerBettina EngelLaura Castañar Lorenz Meinel Ann-Christin Pöppler

Published in: Analytical methods : advancing methods and applications (2024)

There are various commercially available setups for studying drug permeation, which differ in cost and manual labor. We explore an artificial membrane in an NMR tube to assess drug permeation with automated measurements. NMR-based concentrations were validated with HPLC and compared to a conventional setup. Setup-specific challenges and workarounds as well as future setup-designs for this and other applications are discussed.

Keyphrases

magnetic resonance
adverse drug
machine learning
deep learning
drug induced
emergency department
high throughput
mass spectrometry
high performance liquid chromatography