Ten Years of EWAS.

Siyu WeiJunxian TaoJing XuXingyu ChenZhaoyang WangNan ZhangLijiao ZuoZhe JiaHaiyan ChenHongmei SunYubo YanMingming ZhangHongchao LvFanwu KongLian DuanYe MaMingzhi LiaoLiangde XuRennan FengGuiyou LiuThe Ewas ProjectYongshuai Jiang

Published in: Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2021)

Epigenome-wide association study (EWAS) has been applied to analyze DNA methylation variation in complex diseases for a decade, and epigenome as a research target has gradually become a hot topic of current studies. The DNA methylation microarrays, next-generation, and third-generation sequencing technologies have prepared a high-quality platform for EWAS. Here, the progress of EWAS research is reviewed, its contributions to clinical applications, and mainly describe the achievements of four typical diseases. Finally, the challenges encountered by EWAS and make bold predictions for its future development are presented.

Keyphrases

dna methylation
genome wide
gene expression
copy number
current status
high throughput
single cell
resting state
functional connectivity