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New closed-loop insulin systems.

Charlotte K BoughtonRoman Hovorka
Published in: Diabetologia (2021)
Advances in diabetes technologies have enabled the development of automated closed-loop insulin delivery systems. Several hybrid closed-loop systems have been commercialised, reflecting rapid transition of this evolving technology from research into clinical practice, where it is gradually transforming the management of type 1 diabetes in children and adults. In this review we consider the supporting evidence in terms of glucose control and quality of life for presently available closed-loop systems and those in development, including dual-hormone closed-loop systems. We also comment on alternative 'do-it-yourself' closed-loop systems. We remark on issues associated with clinical adoption of these approaches, including training provision, and consider limitations of presently available closed-loop systems and areas for future enhancements to further improve outcomes and reduce the burden of diabetes management.
Keyphrases
  • type diabetes
  • glycemic control
  • cardiovascular disease
  • clinical practice
  • blood pressure
  • high throughput
  • deep learning
  • blood glucose
  • metabolic syndrome
  • weight loss
  • insulin resistance