Synovial membrane-derived mesenchymal progenitor cells from osteoarthritic joints in dogs possess lower chondrogenic-, and higher osteogenic capacity compared to normal joints.
Michelle TeunissenN S AhrensL SnelR NarcisiS A KamaliG J V M van OschB P MeijS C MastbergenK SivasubramaniyanM A TryfonidouPublished in: Stem cell research & therapy (2022)
The OA environment had adverse effects on the regenerative potential of cSM-MPCs, corroborated by decreased CFU, population doubling, and chondrogenic capacity compared to normal cSM-MPCs. OA cSM-MPCs may be a less optimal candidate for the cell-based treatment of OA than normal cSM-MPCs.