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The industrial solvent 1,4-dioxane causes hyperalgesia by targeting capsaicin receptor TRPV1.

Xiaoyi MoQiang LiuLuna GaoChang XieXin WeiPeiyuan PangQuan TianYue GaoYoujing ZhangYuanyuan WangTianchen XiongBo ZhongDongdong LiJing Yao
Published in: BMC biology (2022)
Our results suggest TRPV1 is a co-receptor for 1,4-dioxane and that this accounts for its ability to dysregulate body nociceptive sensation.
Keyphrases
  • neuropathic pain
  • spinal cord
  • spinal cord injury
  • wastewater treatment
  • heavy metals
  • ionic liquid
  • binding protein