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Serum creatinine is a biomarker of progressive denervation in spinal muscular atrophy.

Christiano R R AlvesRen ZhangAlec J JohnstoneReid GarnerPann H NweJennifer J SiranosianKathryn J Swoboda
Published in: Neurology (2019)
These findings indicate that decreased Crn levels reflect disease severity, suggesting that Crn is a candidate biomarker for SMA progression. We conclude that Crn measurements should be included in the routine analysis of all patients with SMA. In future studies, it will be important to determine whether Crn levels respond to molecular and gene therapies.
Keyphrases
  • multiple sclerosis
  • genome wide
  • current status
  • gene expression
  • uric acid
  • metabolic syndrome
  • case control
  • transcription factor