Rotational intraperitoneal pressurized aerosol chemotherapy with paclitaxel and cisplatin: pharmacokinetics, tissue concentrations, and toxicities in a pig model.

Soo Jin Park Eun Ji Lee Aeran Seol Sunwoo Park Jiyeon Ham Ga Won Yim Seung-Hyuk Shim Whasun Lim Suk-Joon Chang Gwonhwa Song Ji-Won Park Hee Seung Kimnull null

Published in: Journal of gynecologic oncology (2022)

Delayed absorption of paclitaxel sprayed by RIPAC into the peritoneum to the bloodstream may lead to higher tissue concentrations at different regions and lower serum concentrations than cisplatin.

Keyphrases

locally advanced
klebsiella pneumoniae
radiation therapy
multidrug resistant
water soluble